deRepentigny J, Mathieu L G, Coallier-Ascah J
Can J Microbiol. 1976 Jul;22(7):1024-33.
In our study of opportunistic pathogens, we have some indication that Staphylococcus aureus can increase resistance in mice against Pseudomonas aeruginosa. Intraperitoneal injections of sublethal doses of S. aureus had a protective effect in mice against lethal doses of P. aeruginosa, more so if living and coagulase-positive S. aureus strains were injected. This protective effect was obtained both with laboratory and freshly isolated hospital strains. The interval between these infections can be extended from 2 h up to 1 week and it is still possible to observe the resistance phenomenon. The increased resistance was accompanied by a decrease in viable units of P. aeruginosa in the peritoneal cavity of mice 6 h after the injection of this species. There was no protection by S. aureus against Candida albicans in similar experimental conditions. These observations indicate that intermicrobial ecology, understood here as the previous presence of another species in a host, may be a significant factor in the resistance to infection with opportunistic pathogens such as P. aeruginosa.
在我们对机会性病原体的研究中，我们有一些迹象表明金黄色葡萄球菌可以增强小鼠对铜绿假单胞菌的抵抗力。腹腔注射亚致死剂量的金黄色葡萄球菌对小鼠抵抗致死剂量的铜绿假单胞菌具有保护作用，如果注射的是活的且凝固酶阳性的金黄色葡萄球菌菌株，这种保护作用更强。无论是实验室菌株还是新分离的医院菌株都能产生这种保护作用。这两种感染之间的间隔时间可以从2小时延长到1周，仍然可以观察到抗性现象。在注射铜绿假单胞菌6小时后，小鼠腹腔内铜绿假单胞菌的活菌数量减少，同时抵抗力增强。在类似的实验条件下，金黄色葡萄球菌对白色念珠菌没有保护作用。这些观察结果表明，微生物间生态学（在这里理解为宿主中先前存在的另一种物种）可能是抵抗机会性病原体（如铜绿假单胞菌）感染的一个重要因素。
