Klockars M, Reitamo S, Adinolfi M
Biol Neonate. 1977;32(5-6):243-9. doi: 10.1159/000241025.
Using the immunoperoxidase method, major changes in the distribution of lysozyme (LZM) were found to occur during fetal development. At 10 weeks of gestation LZM was detected for the first time in the proximal tubules of the kidney. This generally coincides with the reported appearance of LZM in fetal blood and amniotic fluid. The enzyme was observed in lung macrophages and in mononuclear cells of the lamina propria of the small intestine in fetuses 12 and 16 weeks old, respectively. At about 18--20 weeks, LZM-positive mononuclear cells were detected in other tissues tested, such as liver, spleen and thymus. Paneth cells were found to be specifically stained at about 20 weeks of gestation. The timing of the appearance of LZM in the various tissues is discussed in relation to the functional maturation of each organ and the ontogeny of this enzyme in other species.
采用免疫过氧化物酶法，发现溶菌酶（LZM）的分布在胎儿发育过程中发生了重大变化。妊娠10周时，首次在肾脏近端小管中检测到LZM。这通常与胎儿血液和羊水中LZM的报道出现时间一致。分别在12周和16周龄的胎儿的肺巨噬细胞和小肠固有层的单核细胞中观察到该酶。在大约18 - 20周时，在其他测试组织如肝脏、脾脏和胸腺中检测到LZM阳性单核细胞。发现潘氏细胞在妊娠约20周时被特异性染色。讨论了LZM在各种组织中出现的时间与每个器官的功能成熟以及该酶在其他物种中的个体发育的关系。
