γ-谷氨酰胺环转移酶：对ε-（L-γ-谷氨酰基）-L-赖氨酸及相关化合物的特异性
gamma-Glutamylamine cyclotransferase: specificity toward epsilon-(L-gamma-glutamyl)-L-lysine and related compounds.
作者信息
Fink M L, Chung S I, Folk J E
出版信息
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4564-8. doi: 10.1073/pnas.77.8.4564.
Abstract
gamma-Glutamylamine cyclotransferase, an enzyme that catalyzes the conversion of L-gamma-glutamylamines to free amines and 5-oxo-L-proline, was found in rabbit kidney and in various other tissues. The specificity of this enzyme indicates that it functions in the metabolism of products of transglutaminase action; among its substrates are epsilon-(L-gamma-glutamyl)-L-lysine, a derivative of this peptide in which the alpha-amino and carboxyl groups of the lysine moiety are blocked, and L-gamma-glutamyl-polyamine derivatives.
摘要
γ-谷氨酰胺环转移酶是一种催化L-γ-谷氨酰胺转化为游离胺和5-氧代-L-脯氨酸的酶，在兔肾和其他多种组织中均有发现。该酶的特异性表明它在转谷氨酰胺酶作用产物的代谢中发挥作用；其底物包括ε-（L-γ-谷氨酰基）-L-赖氨酸（赖氨酸部分的α-氨基和羧基被封闭的该肽衍生物）以及L-γ-谷氨酰基多胺衍生物。
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