在叙利亚仓鼠细胞中启动嘧啶生物合成的多功能蛋白质中的催化协同作用。 - Suppr

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超能文献

Catalytic synergy in the multifunctional protein that initiates pyrimidine biosynthesis in Syrian hamster cells.

作者信息

Mally M I, Grayson D R, Evans D R

出版信息

J Biol Chem. 1980 Dec 10;255(23):11372-80.

PMID:6108322

Abstract

摘要

相似文献

Catalytic synergy in the multifunctional protein that initiates pyrimidine biosynthesis in Syrian hamster cells.在叙利亚仓鼠细胞中启动嘧啶生物合成的多功能蛋白质中的催化协同作用。

J Biol Chem. 1980 Dec 10;255(23):11372-80.

Controlled proteolysis of the multifunctional protein that initiates pyrimidine biosynthesis in mammalian cells: evidence for discrete structural domains.对启动哺乳动物细胞嘧啶生物合成的多功能蛋白质进行的可控蛋白水解：离散结构域的证据。

Proc Natl Acad Sci U S A. 1981 Nov;78(11):6647-51. doi: 10.1073/pnas.78.11.6647.

Organization of a multifunctional protein in pyrimidine biosynthesis. Analyses of active, tryptic fragments.嘧啶生物合成中多功能蛋白的组织。活性胰蛋白酶片段分析。

J Biol Chem. 1981 May 25;256(10):5220-5.

The overall synthesis of L-5,6-dihydroorotate by multienzymatic protein pyr1-3 from hamster cells. Kinetic studies, substrate channeling, and the effects of inhibitors.仓鼠细胞中多酶蛋白pyr1-3对L-5,6-二氢乳清酸的整体合成。动力学研究、底物通道化及抑制剂的作用。

J Biol Chem. 1980 Dec 10;255(23):11381-95.

Immunochemical analysis of the domain structure of CAD, the multifunctional protein that initiates pyrimidine biosynthesis in mammalian cells.对CAD结构域的免疫化学分析，CAD是一种在哺乳动物细胞中启动嘧啶生物合成的多功能蛋白质。

J Biol Chem. 1985 Dec 15;260(29):15840-9.

Isolation of a multifunctional complex containing the first three enzymes of pyrimidine biosynthesis in drosophila melanogaster.在黑腹果蝇中分离出一种包含嘧啶生物合成前三种酶的多功能复合物。

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Control of pyrimidine biosynthesis in the Ascaris ovary: regulatory properties of glutamine-dependent carbamoyl-phosphate synthetase and copurification of the enzyme with aspartate carbamoyltransferase and dihydroorotase.蛔虫卵巢中嘧啶生物合成的调控：谷氨酰胺依赖性氨甲酰磷酸合成酶的调节特性以及该酶与天冬氨酸氨甲酰转移酶和二氢乳清酸酶的共纯化

Mol Biochem Parasitol. 1980 Mar;1(1):55-68. doi: 10.1016/0166-6851(80)90041-9.

Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis.动物体内嘧啶核苷酸的生物合成：基因、酶以及尿苷一磷酸生物合成的调控

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Studies on channeling of carbamoyl-phosphate in the multienzyme complex that initiates pyrimidine biosynthesis in rat ascites hepatoma cells.对大鼠腹水肝癌细胞中启动嘧啶生物合成的多酶复合物中氨甲酰磷酸通道化的研究。

J Biochem. 1982 Nov;92(5):1431-7. doi: 10.1093/oxfordjournals.jbchem.a134067.

Phosphorylation, allosteric effectors and inter-domain contacts in CAD; their role in regulation of early steps of pyrimidine biosynthesis.CAD中的磷酸化、别构效应物及结构域间相互作用；它们在嘧啶生物合成早期步骤调控中的作用。

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Dihydroorotase from the hyperthermophile Aquifex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis.嗜热栖热菌（Aquifex aeolicus）中的二氢乳清酸酶通过与天冬氨酸转氨甲酰酶的化学计量缔合而被激活，并形成用于嘧啶生物合成的单罐反应器。

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Protein kinase A phosphorylation of the multifunctional protein CAD antagonizes activation by the MAP kinase cascade.多功能蛋白CAD的蛋白激酶A磷酸化作用可拮抗丝裂原活化蛋白激酶级联反应的激活作用。

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Substitutions in the aspartate transcarbamoylase domain of hamster CAD disrupt oligomeric structure.仓鼠CAD天冬氨酸转氨甲酰酶结构域中的取代会破坏寡聚体结构。

Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):97-102. doi: 10.1073/pnas.97.1.97.

Organization of a multifunctional protein in pyrimidine biosynthesis. A domain hypersensitive to proteolysis.嘧啶生物合成中多功能蛋白的组织。对蛋白水解敏感的结构域。

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Molecular compartmentation by enzyme cluster formation. A view over current investigations.通过酶簇形成实现分子区室化。当前研究综述。

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