Wombacher H
Mol Cell Biochem. 1983;56(2):155-64. doi: 10.1007/BF00227216.
Current investigations in different fields of cellular metabolism focus on the phenomenon of molecular compartmentation as an essential part of metabolic control. This type of compartment without surrounding membranes arises from enzyme cluster formation in the cell. The organization of the enzymes ranges from very loose, non-covalent aggregations, sometimes only transiently associated - dependent on metabolic or developmental state of the cell - to the very fixed, even covalently linked structures. These organized multienzyme systems produce a chemical microheterogeneity concerning the metabolite concentrations in the cell. Molecular compartmentation is the description of this chemical microheterogeneity in a biological term.
当前细胞代谢不同领域的研究聚焦于分子区室化现象，将其作为代谢控制的重要组成部分。这种没有周围膜的区室类型源自细胞中酶簇的形成。酶的组织形式范围很广，从非常松散的非共价聚集（有时仅短暂结合，取决于细胞的代谢或发育状态）到非常固定的、甚至共价连接的结构。这些有组织的多酶系统在细胞内代谢物浓度方面产生化学微异质性。分子区室化是以生物学术语对这种化学微异质性的描述。
