Rossi M A, Collares E F, Oliveira J S
J Neural Transm. 1980;49(1-2):117-25. doi: 10.1007/BF01249193.
The levels of noradrenaline, adrenaline, and serotonin in the jejunum and ileum of weanling rats fed protein-free (deficient) and high-protein (control) diets were analyzed. The concentration of noradrenaline of the deficient rats was markedly increased, both in the jejunum (0.430 +/- 0.039 microgram/g vs. 0.188 +/- 0.019 microgram/g in the control animals, +228%, P < 0.001) and in the ileum (0.492 +/- 0.041 microgram/g vs. 0.212 +/- 0.014 microgram/g in the control rats, +232%, P < 0.001). However, the levels of adrenaline and serotonin were unaltered in deficient rats as compared to controls, both in the jejunum (0.049 +/- 0.009 microgram/g of adrenaline and 1.233 +/- 0.178 microgram/g of serotonin vs. 0.047 +/- 0.006 microgram/g of adrenaline and 1.364 +/- 0.131 microgram/g of serotonin in the controls) and in the ileum (0.027 +/- 0.005 microgram/g of adrenaline and 0.902 +/- 0.150 microgram/g of serotonin vs. 0.038 +/- 0.006 microgram/g of adrenaline and 1.118 +/- 0.192 microgram/g of serotonin in the controls). In view of these results, it can be speculated that the abdominal distension and the reduced intestinal motility usually seen in the states of protein malnutrition could be caused, at least in part, by the accumulation of noradrenaline in the intestine.
分析了喂食无蛋白（缺乏）和高蛋白（对照）饮食的断奶大鼠空肠和回肠中去甲肾上腺素、肾上腺素和血清素的水平。缺乏组大鼠空肠中去甲肾上腺素浓度显著升高（0.430±0.039微克/克，对照动物为0.188±0.019微克/克，增加228%，P<0.001），回肠中也显著升高（0.492±0.041微克/克，对照大鼠为0.212±0.014微克/克，增加232%，P<0.001）。然而，与对照组相比，缺乏组大鼠空肠（肾上腺素0.049±0.009微克/克、血清素1.233±0.178微克/克，对照组为肾上腺素0.047±0.006微克/克、血清素1.364±0.131微克/克）和回肠（肾上腺素0.027±0.005微克/克、血清素0.902±0.150微克/克，对照组为肾上腺素0.038±0.006微克/克、血清素1.118±0.192微克/克）中的肾上腺素和血清素水平未发生改变。鉴于这些结果，可以推测，蛋白质营养不良状态下常见的腹胀和肠道蠕动减弱至少部分是由去甲肾上腺素在肠道中的蓄积引起的。
