垂体和大脑中的免疫反应性强啡肽
Immunoreactive dynorphin in pituitary and brain.
作者信息
Goldstein A, Ghazarossian V E
出版信息
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6207-10. doi: 10.1073/pnas.77.10.6207.
Abstract
Distribution of the potent opioid peptide dynorphin has been determined in pituitary gland (pig, beef, rat), in the various regions of rat brain, and in rat spinal cord, by using a highly specific antiserum. By gel permeation chromatography in 4 M guanidine, the porcine pituitary immunoreactivity is found in a major peak of apparent molecular weight about 1700 and a minor peak of about 3400. Similar peaks are found in rat pituitary extracts, whereas rat brain contains, in addition, two peaks of larger apparent molecular weight. In the pituitary, immunoreactive dynorphin is found predominantly in pars nervosa. In the central nervous system, it is distributed widely, with highest concentrations in hypothalamus, medulla-pons, midbrain, and spinal cord. Although dynorphin contains leucine-enkephalin, the regional distribution of dynorphin is different from that of enkephalin or of any other known opioid peptide.
摘要
利用一种高度特异性抗血清，已确定强效阿片样肽强啡肽在垂体（猪、牛、大鼠）、大鼠脑的各个区域以及大鼠脊髓中的分布。通过在4M胍中进行凝胶渗透色谱分析，发现猪垂体中的免疫反应性存在于一个表观分子量约为1700的主要峰和一个约为3400的次要峰中。在大鼠垂体提取物中也发现了类似的峰，而大鼠脑中还含有另外两个表观分子量较大的峰。在垂体中，免疫反应性强啡肽主要存在于神经垂体。在中枢神经系统中，它分布广泛，在下丘脑、延髓-脑桥、中脑和脊髓中浓度最高。尽管强啡肽含有亮氨酸脑啡肽，但其区域分布与脑啡肽或任何其他已知阿片样肽的分布不同。
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