自发性高血压大鼠中枢神经系统和垂体中强啡肽肽水平。
Levels of dynorphin peptides in the central nervous system and pituitary gland of the spontaneously hypertensive rat.
作者信息
Tan-No K, Terenius L, Silberring J, Nylander I
机构信息
Department of Pharmacology, Tohoku College of Pharmacy, Sendai, Japan.
出版信息
Neurochem Int. 1997 Jul;31(1):27-32. doi: 10.1016/s0197-0186(96)00137-4.
The levels of dynorphin A-like immunoreactivity (Dyn A-LI) and dynorphin B-like immunoreactivity (Dyn B-LI) were determined in various regions of brain, spinal cord and pituitary gland in spontaneously hypertensive rats (SHRs) as compared with the normotensive Wistar-Kyoto rats (WKYs). SHRs had significantly lower levels of Dyn A-LI and Dyn B-LI in the neurointermediate pituitary lobe and in the hippocampus. Conversely, the levels of Dyn A-LI and Dyn B-LI were higher in the hypothalamus, striatum and periaqueductal gray of the SHRs.
与正常血压的Wistar-Kyoto大鼠（WKYs）相比，测定了自发性高血压大鼠（SHRs）脑、脊髓和垂体各区域中强啡肽A样免疫反应性（Dyn A-LI）和强啡肽B样免疫反应性（Dyn B-LI）的水平。SHRs神经垂体中间叶和海马中的Dyn A-LI和Dyn B-LI水平显著较低。相反，SHRs下丘脑、纹状体和导水管周围灰质中的Dyn A-LI和Dyn B-LI水平较高。
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