Macdonald G J, Greeley L K, Beattie C W
Int J Fertil. 1980;25(3):198-202.
LH-RH causes pregnancy failure in hypophysectomized rats. This study investigated whether this failure was due to an action of LH-RH upon the fetus, placenta, uterus, or ovary. Pseudopregnant, hypophysectomized, prolactin treated rats were subjected to uterine trauma to develop the decidual cell response or were hysterectomized. Deciduoma formation and serum progesterone valves were significantly decreased in all LH-RH treated animals. These observations suggest that LH-RH inhibits prolactin maintained progesterone secretion in hypophysectomized rats by a direct action of the hormone on the ovary.
促黄体生成素释放激素（LH-RH）会导致垂体切除的大鼠出现妊娠失败。本研究调查了这种失败是否是由于LH-RH对胎儿、胎盘、子宫或卵巢的作用所致。对假孕、垂体切除、接受催乳素治疗的大鼠进行子宫创伤以引发蜕膜细胞反应，或进行子宫切除。在所有接受LH-RH治疗的动物中，蜕膜瘤形成和血清孕酮水平均显著降低。这些观察结果表明，LH-RH通过该激素对卵巢的直接作用，抑制垂体切除大鼠中催乳素维持的孕酮分泌。
