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转谷氨酰胺酶修饰HLA - A和 - B抗原的羧基末端细胞内区域。

Transglutaminase modifies the carboxy-terminal intracellular region of HLA-A and -B antigens.

作者信息

Pober J S, Strominger J L

出版信息

Nature. 1981 Feb 26;289(5800):819-21. doi: 10.1038/289819a0.

DOI:10.1038/289819a0
PMID:6110191
Abstract

The HLA-A and -B antigens, encoded in the major histocompatibility complex, are transmembrane proteins whose carboxy termini project inwards from the cell membrane. The intracellular region of the HLA-B7 antigen is known to include two glutamine residues. We have used guinea pig transglutaminase to show that in vitro the enzyme couples amines specifically to glutamine residues in the carboxy-terminal region of the HLA-B7 and -A2 antigens. The specificity of this reaction has an immediate practical significance, but may also have a wider biological interest.

摘要

主要组织相容性复合体中编码的HLA - A和 - B抗原是跨膜蛋白，其羧基末端从细胞膜向内突出。已知HLA - B7抗原的细胞内区域包含两个谷氨酰胺残基。我们使用豚鼠转谷氨酰胺酶证明，在体外该酶能将胺类特异性地连接到HLA - B7和 - A2抗原羧基末端区域的谷氨酰胺残基上。这种反应的特异性具有直接的实际意义，但也可能具有更广泛的生物学意义。

相似文献

1
Transglutaminase modifies the carboxy-terminal intracellular region of HLA-A and -B antigens.转谷氨酰胺酶修饰HLA - A和 - B抗原的羧基末端细胞内区域。
Nature. 1981 Feb 26;289(5800):819-21. doi: 10.1038/289819a0.
2
Transglutaminase-catalysed incorporation of putrescine into denatured cytochrome. Preparation of a mono-substituted derivative reactive with cytochrome c oxidase.转谷氨酰胺酶催化腐胺掺入变性细胞色素。制备与细胞色素c氧化酶反应的单取代衍生物。
Biochim Biophys Acta. 1981 Sep 29;670(2):214-21. doi: 10.1016/0005-2795(81)90012-x.
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Phosphorylation in vivo and in vitro of human histocompatibility antigens (HLA-A and HLA-B) in the carboxy-terminal intracellular domain.人组织相容性抗原（HLA - A和HLA - B）在羧基末端细胞内结构域的体内和体外磷酸化作用。
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Catalytic formation of epsilon-(gamma-glutamyl)lysine in guinea pig liver transglutaminase.豚鼠肝脏转谷氨酰胺酶中ε-（γ-谷氨酰基）赖氨酸的催化形成
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Structure of the human class I histocompatibility antigen, HLA-A2.人类I类组织相容性抗原HLA - A2的结构
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Role of the intrinsic transglutaminase in the Ca2+-mediated crosslinking of erythrocyte proteins.内源性转谷氨酰胺酶在钙离子介导的红细胞蛋白交联中的作用。
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Human major histocompatibility complex class I antigens: residues 61-83 of the HLA-B7 heavy chain specify an alloreactive site.
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Coupling of amines to and cross-linking of endogenous cytosol or membrane proteins by hepatic transglutaminase.肝脏转谷氨酰胺酶介导的胺与内源性胞质溶胶或膜蛋白的偶联及交联作用。
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Allorecognition of purified major histocompatibility complex glycoproteins by cytotoxic T lymphocytes.细胞毒性T淋巴细胞对纯化的主要组织相容性复合体糖蛋白的同种异体识别。
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引用本文的文献

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Differences in polyamine availability and insertion into fibronectins released from normal and transformed cells.正常细胞和转化细胞释放的纤连蛋白中多胺可用性及插入情况的差异。
Biochem J. 1983 Jan 15;210(1):137-44. doi: 10.1042/bj2100137.
2
Cell surface properties of HLA antigens on Epstein-Barr virus-transformed cell lines.爱泼斯坦-巴尔病毒转化细胞系上HLA抗原的细胞表面特性
Proc Natl Acad Sci U S A. 1982 Jan;79(2):608-12. doi: 10.1073/pnas.79.2.608.
3
Functional aspects of class I MHC molecule domains.I类主要组织相容性复合体（MHC）分子结构域的功能方面
Surv Immunol Res. 1984;3(2-3):179-83. doi: 10.1007/BF02918789.
4
Lens transglutaminase selects specific beta-crystallin sequences as substrate.晶状体转谷氨酰胺酶选择特定的β-晶状体蛋白序列作为底物。
Proc Natl Acad Sci U S A. 1984 Nov;81(22):7017-20. doi: 10.1073/pnas.81.22.7017.
5
Transglutaminase activation: significance with respect to immunologic phenomena.转谷氨酰胺酶激活：与免疫现象相关的意义
Surv Immunol Res. 1982;1(4):297-304. doi: 10.1007/BF02918540.
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Post-translational modification of neuronal proteins: evidence for transglutaminase activity in R2, the giant cholinergic neuron of Aplysia.神经元蛋白质的翻译后修饰：海兔巨大胆碱能神经元R2中谷氨酰胺转移酶活性的证据。
Proc Natl Acad Sci U S A. 1982 Jun;79(11):3442-6. doi: 10.1073/pnas.79.11.3442.
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A role for transglutaminase in glucose-stimulated insulin release from the pancreatic beta-cell.转谷氨酰胺酶在胰腺β细胞葡萄糖刺激的胰岛素释放中的作用。
Biochem J. 1986 Apr 1;235(1):269-78. doi: 10.1042/bj2350269.