吞噬作用刺激培养的巨噬细胞释放一种慢反应物质。
Phagocytosis stimulates the release of a slow reacting substance in cultured macrophages.
作者信息
Bretz U, Dewald B, Payne T, Schnyder J
出版信息
Br J Pharmacol. 1980;71(2):631-4. doi: 10.1111/j.1476-5381.1980.tb10983.x.
Abstract
1 A slow-reacting substance (SRS) was released from non-elicited mouse peritoneal macrophages during phagocytosis of zymosan particles, whereas no detectable SRS was produced by resting cells. 2 The macrophage SRS induced a delayed and slow contraction of the guinea-pig ileum but not of the chick rectum. 3 The myotonic activity was antagonized by low concentrations of FPL 55712 (sodium 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1 -benzopyran-2 carboxylate) but was not affected by mepyramine or hyoscine, and was not associated with tachyphylaxis. 4 SRS release was increased by indomethacin and was abolished by the lipoxygenase and cyclooxygenase inhibitor, BW755C (3-amino-1-[m-(trifluoromethyl)-phenyl]-2-pyrazoline). 5 Addition of exogenous arachidonic acid or cysteine enhanced SRS production.
摘要
- 在酵母聚糖颗粒吞噬过程中，未致敏的小鼠腹腔巨噬细胞释放出一种慢反应物质（SRS），而静止细胞未产生可检测到的SRS。2. 巨噬细胞SRS可引起豚鼠回肠延迟性缓慢收缩，但对鸡直肠无此作用。3. 低浓度的FPL 55712（7-[3-(4-乙酰基-3-羟基-2-丙基苯氧基)-2-羟基丙氧基]-4-氧代-8-丙基-4H-1-苯并吡喃-2-羧酸钠）可拮抗强直性活动，而美吡拉敏或东莨菪碱对此无影响，且该活动与快速耐受性无关。4. 吲哚美辛可增加SRS的释放，脂氧合酶和环氧化酶抑制剂BW755C（3-氨基-1-[间-(三氟甲基)-苯基]-2-吡唑啉）可消除SRS的释放。5. 添加外源性花生四烯酸或半胱氨酸可增强SRS的产生。
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