Belal S, Elsayed M A, Abdel-Hamid M E, Abdine H
J Pharm Sci. 1981 Feb;70(2):127-30. doi: 10.1002/jps.2600700204.
A simple and sensitive spectrophotometric method is described for the assay of naphazoline, clemizole, penicillin G sodium, and piperazine. The method was based on the formation of a charge transfer complex between these drugs as n-donors and chloranil, the pi-acceptor. Conformity to Beer's law enabled the assay of dosage forms of these drugs. Compared with official methods, the results obtained were of equal accuracy. A more detailed investigation of th naphazoline-chloranil complex was made with respect to its composition, association constant, and free energy change.
描述了一种用于测定萘甲唑啉、氯苯那敏、青霉素G钠和哌嗪的简单且灵敏的分光光度法。该方法基于这些作为n供体的药物与作为π受体的四氯对苯醌之间形成电荷转移络合物。符合比尔定律使得能够对这些药物的剂型进行测定。与官方方法相比，所得结果具有同等的准确性。对萘甲唑啉 - 四氯对苯醌络合物的组成、缔合常数和自由能变化进行了更详细的研究。
