Nabeshima T, Kameyama T
Nihon Yakurigaku Zasshi. 1977 Nov;73(8):961-72. doi: 10.1254/fpj.73.961.
The anti-nociceptive dose of difenamizole, morphine, aminopyrine and aspirin was studied for effects on behavior maintained by schedule of positive reinforcement. Male, albino rats were trained to press a lever for food pellets on a fixed-ratio (FR) 10 and 30 schedule of reinforcement or a differential reinforcement of low rates of responding (DRL) schedule. Difenamizole (200 and 400 mg/kg, p.o.) produced a dose-related decrease in the response under FR-10 schedule. The response rate decrease observed under the FR-10 schedule was similar to that resulting from the oral administration of 400 mg/kg of aminopyrine. Response in the FR-30 schedule was not affected by any dose of difenamizole (100 approximately 400 mg/kg, p.o.) and aminopyrine (200 approximately 400 mg/kg, p.o.). In the response maintained by the DRL schedule, the overall response rate and the mean interresponse time were not altered significantly by most doses of difenamizole, aminopyrine and aspirin given, however, food reinforcement was decreased significantly with ingestion of these drugs. Morphine (20 mg/kg, p.o.) shortened the mean interresponse time and increased the response in DRL schedule. These results suggest that the central action of difenamizole is similar to that produced by aminopyrine, but not that produced by morphine.
研究了双苯胺唑、吗啡、氨基比林和阿司匹林的抗伤害感受剂量对由阳性强化程序维持的行为的影响。雄性白化大鼠被训练在固定比率（FR）10和30的强化程序或低反应率差异强化（DRL）程序下按压杠杆以获取食丸。双苯胺唑（200和400毫克/千克，口服）在FR-10程序下使反应呈剂量相关下降。在FR-10程序下观察到的反应率下降与口服400毫克/千克氨基比林所导致的相似。FR-30程序中的反应不受任何剂量双苯胺唑（100至400毫克/千克，口服）和氨基比林（200至400毫克/千克，口服）的影响。在DRL程序维持的反应中，大多数剂量的双苯胺唑、氨基比林和阿司匹林给药后，总体反应率和平均反应间隔时间没有显著改变，然而，摄入这些药物后食物强化显著减少。吗啡（20毫克/千克，口服）缩短了平均反应间隔时间并增加了DRL程序中的反应。这些结果表明双苯胺唑的中枢作用与氨基比林产生的相似，但与吗啡产生的不同。
