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[生物胺与双苯胺唑在热诱导反射中的镇痛作用之间的关系]

[Relationship between biogenic amines and analgesic action of difenamizole in heat induced reflexes].

作者信息

Kameyama T, Nabeshima T

出版信息

Nihon Yakurigaku Zasshi. 1976 Jul;72(5):543-56. doi: 10.1254/fpj.72.543.

Abstract

Effects of drugs that modify catecholaminergic or tryptaminergic mechanisms were determined in experimental animals regarding the analgesic action of difenamizole, morphine, and aminopyrine. Analgesia was assessed by the hot plate method in mice and the hot water induced tail withdrawal reflex in rats. Both 5-hydroxytryptophan (5-HTP) and L-dopa potentiated the analgesic action of morphine, but antagonized the action of difenamizole in the hot plate test. p-Chlorophenylalanine (pCPA), alpha-methyl-p-tyrosine (alpha-MT), and reserpine antagonized the effect of morphine as assessed by this same test. alpha-MT potentiated the analgesic action of difenamizole. The analgesic action of aminopyrine was hardly modified in the hot plate method by pretreatment with 5-HTP, pCPA, L-dopa, and alpha-MT. In rats, 5-HTP antagonized the effect of morphine, while pCPA, L-dopa, and alpha-MT caused no appreciable change in the analgesic action of morphine in the hot water induced tail withdrawal reflex. The effect of difenamizole was not modified by pretreatment with these monoamine-related drugs. On the other hand, brain 5-hydroxytryptamine content was increased by pretreatment with 5-HTP in both tests. These results suggest that the analgesic action of difenamizole and morphine, as measured in the hot plate test in mice, may be mediated by catecholamines and 5-hydroxytryptamine, but that other mechanisms may be involved in the hot water induced tail withdrawal relfex in rats. In addition, the biogenic amines may play a different role depending on the type of analgesic.

摘要

在实验动物中,研究了改变儿茶酚胺能或色胺能机制的药物对双苯胺咪唑、吗啡和氨基比林镇痛作用的影响。通过热板法评估小鼠的镇痛效果,通过热水诱导大鼠的甩尾反射评估大鼠的镇痛效果。5-羟色氨酸(5-HTP)和左旋多巴均增强了吗啡的镇痛作用,但在热板试验中拮抗了双苯胺咪唑的作用。对氯苯丙氨酸(pCPA)、α-甲基对酪氨酸(α-MT)和利血平通过相同试验评估拮抗了吗啡的作用。α-MT增强了双苯胺咪唑的镇痛作用。在热板法中,用5-HTP、pCPA、左旋多巴和α-MT预处理后,氨基比林的镇痛作用几乎没有改变。在大鼠中,5-HTP拮抗了吗啡的作用,而pCPA、左旋多巴和α-MT在热水诱导的甩尾反射中对吗啡的镇痛作用没有引起明显变化。用这些与单胺相关的药物预处理后,双苯胺咪唑的作用没有改变。另一方面,在两项试验中,用5-HTP预处理均增加了脑5-羟色胺含量。这些结果表明,在小鼠热板试验中测得的双苯胺咪唑和吗啡的镇痛作用可能由儿茶酚胺和5-羟色胺介导,但在大鼠热水诱导的甩尾反射中可能涉及其他机制。此外,生物胺可能根据镇痛类型发挥不同作用。

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