Heikkila J J, Brown I R
J Neurochem. 1981 Mar;36(3):1219-28. doi: 10.1111/j.1471-4159.1981.tb01721.x.
The intravenous administration of LSD to young adult rabbits resulted in the disaggregation of both free and membrane-bound classes of brain polysomes. Based on the analysis of LSD dosage and the time course of the LSD-induced brain polysome shift, it was found that free polysomes were more sensitive to the drug than the membrane-bound polysome fraction. LSD-induced hyperthermia may be involved in the disaggregation of free and membrane-bound polysomes, since a correlation was found between the extent of LSD-induced hyperthermia and the degree of brain polysome shift. Prevention of LSD-induced hyperthermia by maintaining the animal at 4 degrees C blocked the disaggregation of both polysome classes. Induction of hyperthermia by elevation of ambient temperature also resulted in a shift in free and membrane-bound polysomes. In all cases the disaggregation of polysomes to monosomes was not caused by RNase activation. During polysome disaggregation, polyadenylated mRNA associated with both free and membrane-bound polysomes was not degraded but was relocalized from polysomes to monosomes.
给成年幼兔静脉注射麦角酸二乙酰胺（LSD）会导致脑多核糖体的游离类和膜结合类都发生解聚。基于对LSD剂量以及LSD诱导的脑多核糖体转移的时间进程分析，发现游离多核糖体比膜结合多核糖体部分对该药物更敏感。LSD诱导的体温过高可能与游离和膜结合多核糖体的解聚有关，因为在LSD诱导的体温过高程度与脑多核糖体转移程度之间发现了相关性。通过将动物维持在4摄氏度来预防LSD诱导的体温过高，可阻止这两类多核糖体的解聚。通过升高环境温度诱导体温过高也会导致游离和膜结合多核糖体发生转移。在所有情况下，多核糖体解聚为单核糖体并非由核糖核酸酶激活引起。在多核糖体解聚过程中，与游离和膜结合多核糖体相关的多聚腺苷酸化信使核糖核酸（mRNA）并未降解，而是从多核糖体重新定位到单核糖体。
