用长效莫迪替尼联合其他精神药物及氯氮平治疗对治疗有抵抗性的偏执型精神分裂症患者

[Treatment of therapeutically resistant paranoid schizophrenic patients with Moditen-depot combined with other psychotropic drugs and Leponex].

作者信息

Gamburg A L, Aranovich A G, Kotel'kevich Iu N, Omorokov B M, Rasniuk V A

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1980;80(8):1211-6.

Abstract

The results of treating 251 therapeutically resistant patients with paranoid schizophrenia by moditen-depo, its combination with other psychotic drugs or leponex was compared. The results obtained indicate that a comprehensive treatment (moditen-depo with other psychotropic drugs) and by leponex may be successfully applied to some of the paranoid schizophrenics resistant to moditen-depo and other neuroleptic drugs or their combinations. Comprehensive treatment appeared to be more effective in systematized delusions, the syndrome of psychic automatisms and in a crude emotional-volitional defect. Treatment by leponex was more efficacious in emotionally saturated nonsystematized delusions, pronounced disordered behaviour and mild manifestation of deterioration.

摘要

比较了使用长效莫迪替尼、其与其他抗精神病药物联合或使用氯氮平治疗251例偏执型精神分裂症难治性患者的结果。所获结果表明，综合治疗（长效莫迪替尼与其他精神药物联合）以及使用氯氮平可成功应用于部分对长效莫迪替尼及其他抗精神病药物或其联合治疗耐药的偏执型精神分裂症患者。综合治疗在系统性妄想、精神自动症综合征及明显的情感意志缺陷方面似乎更有效。氯氮平治疗在情感丰富的非系统性妄想、明显的行为紊乱及轻度衰退表现方面更有效。