Mályusz M, Braun D
Enzyme. 1981;26(1):32-42. doi: 10.1159/000459144.
The urinary output of gamma-glutamyl-transpeptidase (gamma GT) and of N-acetyl-beta-D-glucosaminidase (NAG) was studied with "two-kidney Goldblatt hypertension' 3-6, 16-19 and 30-33 weeks after eliciting high blood pressure. gamma GT excretion rate of normotensive males was higher than that of females, while the activity of the renal tissue was on the same level. gamma GT output of hypertensive males was elevated in the early and in the middle stages of the disease, it was subnormal in the late stage. In females gamma GT output increased in animals with excessively high blood pressure (less than 200 mm Hg) only. gamma GT output correlated with the tissue activity in males only. In all animals there was an inverse, linear correlation between tissue gamma GT activity and the hydroxyproline content. The pattern of the NAG output was similar to that of gamma GT, however, excretion of NAG showed no sex differences and remained high in the late stage of the disease, too. Nephrosclerosis was less pronounced in female Goldblatt rats than in males.
在引发高血压后的3 - 6周、16 - 19周以及30 - 33周，采用“双肾型肾血管性高血压模型”对γ-谷氨酰转肽酶（γGT）和N-乙酰-β-D-氨基葡萄糖苷酶（NAG）的尿排泄量进行了研究。血压正常的男性γGT排泄率高于女性，而肾组织的活性处于同一水平。高血压男性的γGT排泄量在疾病早期和中期升高，在后期低于正常水平。仅在血压过高（低于200 mmHg）的雌性动物中，γGT排泄量增加。仅在男性中，γGT排泄量与组织活性相关。在所有动物中，组织γGT活性与羟脯氨酸含量之间呈负线性相关。NAG排泄模式与γGT相似，然而，NAG的排泄无性别差异，且在疾病后期也保持在较高水平。雌性戈德布拉特大鼠的肾硬化程度比雄性轻。
