Kaufmann S H, Hofmann H P, Kreiskott H
Arzneimittelforschung. 1981;31(2):335-7.
In rats hyperphagia could be reversibly induced by intracerebroventricular infusion of sodium pentobarbital. Hyperphagia was elicited in a dose dependent manner, the optimal infusion rate being 1000 micrograms/h sodium pentobarbital. At this rate, feeding behaviour was induced selectively, with only minor side effects being apparent. Systemic application of d-methamphetamine or propylhexedrine given prior to infusion resulted in a dose dependent reduction of hyperphagia. The method, therefore, could be useful for testing putative anorexigenic compounds in hyperphagic rats.
在大鼠中，通过脑室内注入戊巴比妥钠可可逆地诱导食欲亢进。食欲亢进以剂量依赖性方式引发，最佳注入速率为每小时1000微克戊巴比妥钠。以该速率，仅选择性地诱导进食行为，且仅出现轻微的副作用。在注入前全身应用d-甲基苯丙胺或丙己君导致食欲亢进呈剂量依赖性降低。因此，该方法可能有助于测试食欲亢进大鼠中假定的厌食化合物。
