Wallach M B, Dawber M, McMahon M, Rogers C
Pharmacol Biochem Behav. 1977 May;6(5):529-31. doi: 10.1016/0091-3057(77)90112-5.
Humans often respond to stress by overeating. A rat model of hyperphagia induced by a stressful tail-pinch has been described. Consumption of sweetened condensed milk by vaive rats was measured durin the stress. This milk drinking was prevented by pretreatment with d-amphetamine, chlorphentermine, diethylpropion, fenfluramine, methamphetamine, morphine, chlorpromazine and haloperidol. The benzodiazepines chlordiazepoxide and diazepam increased the hyperphagia. The relevance of dopaminergic agonistic and antagonist activities to anorexigenic activity are questioned.
人类经常通过暴饮暴食来应对压力。一种由应激性尾部夹捏诱导的贪食大鼠模型已被描述。在应激期间测量了正常大鼠对甜炼乳的摄入量。用右旋苯丙胺、氯苯丁胺、二乙丙胺苯丙酮、芬氟拉明、甲基苯丙胺、吗啡、氯丙嗪和氟哌啶醇预处理可防止这种饮奶行为。苯二氮䓬类药物氯氮卓和地西泮增加了贪食行为。多巴胺能激动剂和拮抗剂活性与厌食活性的相关性受到质疑。
