Agarwal K N, Bhatia B D, Batta R K, Singla P N, Shankar R
Am J Clin Nutr. 1981 May;34(5):924-7. doi: 10.1093/ajcn/34.5.924.
The erythrocyte enzymes of glutamic acid metabolism (glutaminase I, glutaminase II, glutamic acid decarboxylase, glutamine synthetase, and transaminases) and related amino acids (glutamine, glutamic acid, aspartic acid, alanine, and gamma-aminobutyric acid) were estimated in 69 children with protein-energy malnutrition, 13 with nephrosis, and 10 with Indian childhood cirrhosis. Twenty-one apparently healthy children served as controls. There was a significant increase in the activities of erythrocytic glutaminase I, glutaminase II, glutamic acid decarboxylase, and glutamine synthetase in all the three hypoproteinemic states, while the activities of the transaminases showed a decrease in all the conditions. The concentrations of all the amino acids were significantly increased in both the varieties of protein-energy malnutrition (edematous and nonedematous). In nephrosis and Indian childhood cirrhosis, aspartic acid, alanine, and gamma-aminobutyric acid showed a significant rise. The concentration of glutamic acid was also significantly increased in nephrosis. The observations of the present study suggest an increase in intracellular production of glutamic acid in hypoproteinemia.
对69名蛋白质 - 能量营养不良儿童、13名肾病患儿和10名印度儿童肝硬化患儿的红细胞谷氨酸代谢酶（谷氨酰胺酶I、谷氨酰胺酶II、谷氨酸脱羧酶、谷氨酰胺合成酶和转氨酶）以及相关氨基酸（谷氨酰胺、谷氨酸、天冬氨酸、丙氨酸和γ-氨基丁酸）进行了测定。21名明显健康的儿童作为对照。在所有三种低蛋白血症状态下，红细胞谷氨酰胺酶I、谷氨酰胺酶II、谷氨酸脱羧酶和谷氨酰胺合成酶的活性均显著增加，而转氨酶的活性在所有情况下均降低。在蛋白质 - 能量营养不良的两种类型（水肿型和非水肿型）中，所有氨基酸的浓度均显著增加。在肾病和印度儿童肝硬化中，天冬氨酸、丙氨酸和γ-氨基丁酸显著升高。肾病中谷氨酸的浓度也显著增加。本研究的观察结果表明低蛋白血症时细胞内谷氨酸生成增加。
