Sastre y Hernández M S, Hentschel H D, Fichte K
J Int Med Res. 1981;9(3):199-202. doi: 10.1177/030006058100900309.
Lormetazepam (Noctamid) at a dosage of 1 mg was compared with diazepam (Valium) at a dosage of 5 mg in a 7-day double-blind study. The study involved fifty patients in the lormetazepam group and fifty patients in the diazepam group. All the patients were suffering from sleep disorders as a concomitant symptom of general diseases. Lormatazepam was significantly better than diazepam in the: -Reduction of the time taken to fall asleep (p less than 0.05) -Prolongation of the duration of uninterrupted sleep (p less than 0.05) -Reduction of the frequency of awakening (p less than 0.05). Lormetazepam displayed no hang-over effects or other side-effects and, in this respect too, was significantly superior to diazepam (p less than 0.05).
在一项为期7天的双盲研究中，对剂量为1毫克的氯氮卓[艹卓]（诺他米特）与剂量为5毫克的地西泮（安定）进行了比较。该研究涉及氯氮卓[艹卓]组的50名患者和地西泮组的50名患者。所有患者均患有作为一般疾病伴随症状的睡眠障碍。氯氮卓[艹卓]在以下方面明显优于地西泮：入睡时间缩短（p<0.05）、无间断睡眠持续时间延长（p<0.05）、觉醒频率降低（p<0.05）。氯氮卓[艹卓]未显示宿醉效应或其他副作用，在这方面也明显优于地西泮（p<0.05）。
