Yuki T, Bradford B U, Thurman R G
Pharmacol Biochem Behav. 1980;13 Suppl 1:67-71. doi: 10.1016/s0091-3057(80)80011-6.
Gastric intubation of female Sprague-Dawley rats (80--150 g) with one large dose (5 g/kg) of ethanol doubled both hepatic oxygen uptake and ethanol metabolism within 2.5 hr in the perfused rat liver (Swift Increase in Alcohol Metabolism--SIAM). Hepatic oxygen uptake could also be elevated by direct infusion of epinephrine and glucagon into the perfused liver. Alcohol treatment produced significant increases in circulating epinephrine, norepinephrine and glucose but did not effect levels of plasma immunoreactive insulin. Administration of alpha- and beta-adrenergic blocking agents, adrenalectomy and hypophysectomy prevented the increase in oxygen uptake due to ethanol treatment. These data suggest that catecholamines and possibly other hormones play an important role in the mechanism of the Swift Increase in Alcohol Metabolism (SIAM).
给体重80 - 150克的雌性斯普拉格-道利大鼠经胃一次性大剂量（5克/千克）给予乙醇，在灌注大鼠肝脏中，2.5小时内肝脏氧摄取量和乙醇代谢均增加了一倍（酒精代谢快速增加——SIAM）。通过向灌注肝脏直接输注肾上腺素和胰高血糖素，也可提高肝脏氧摄取量。酒精处理使循环中的肾上腺素、去甲肾上腺素和葡萄糖显著增加，但不影响血浆免疫反应性胰岛素水平。给予α和β肾上腺素能阻断剂、肾上腺切除术和垂体切除术可阻止乙醇处理导致的氧摄取增加。这些数据表明，儿茶酚胺以及可能的其他激素在酒精代谢快速增加（SIAM）机制中起重要作用。
