Yuki T, Thurman R G
Curr Alcohol. 1981;8:445-52.
Gastric intubation of female Sprague-Dawley rats with 5 g of ethanol/kg body wt doubled oxygen and ethanol uptake by the isolated perfused rat liver after only 2-5 h of treatment (Swift Increase in Alcohol Metabolism). Diminished ATP generation via glycolysis accounts for a portion of the increased oxygen uptake. These data indicate that at least part of the stimulated oxygen uptake after treatment with ethanol is a result of lower rates of glycolytic ATP generation resulting from hormone action. The ADP not phosphorylated in the cytocol enters the mitochondrion where it stimulates oxygen uptake.
给雌性斯普拉格-道利大鼠胃内灌注5克乙醇/千克体重，仅在处理2 - 5小时后，分离灌注的大鼠肝脏的氧气摄取量和乙醇摄取量就增加了一倍（酒精代谢迅速增加）。通过糖酵解产生的ATP减少是氧气摄取增加的部分原因。这些数据表明，乙醇处理后刺激的氧气摄取至少部分是由于激素作用导致糖酵解ATP生成速率降低的结果。未在细胞质中磷酸化的ADP进入线粒体，在那里刺激氧气摄取。
