急性和重复使用抗精神病药物治疗诱导大鼠海马结构、隔区和纹状体中3,4-二羟基苯乙酸（DOPAC）水平的差异变化。

Differential changes in DOPAC levels in the hippocampal formation, septum and striatum of the rat induced by acute and repeated neuroleptic treatment.

作者信息

Scatton B

出版信息

Eur J Pharmacol. 1981 May 22;71(4):499-503. doi: 10.1016/0014-2999(81)90196-5.

Abstract

Acute administration of haloperidol, sulpiride and chlorpromazine produces an elevation of hippocampal, septal and striatal DOPAC levels. The ED50 of haloperidol is similar in all areas but the maximal effect is much lower in the hippocampal formation than in septum and striatum. Repeated administration (11 days) of haloperidol causes a less pronounced increase (tolerance) in DOPAC levels in all regions investigated than acute treatment, the hippocampal formation being the most susceptible to this tolerance.

摘要

急性给予氟哌啶醇、舒必利和氯丙嗪会使海马、隔区和纹状体的3,4-二羟基苯乙酸（DOPAC）水平升高。氟哌啶醇的半数有效剂量（ED50）在所有区域相似，但海马结构中的最大效应远低于隔区和纹状体。与急性给药相比，重复给予氟哌啶醇（11天）导致所有研究区域的DOPAC水平升高幅度较小（耐受性），海马结构对这种耐受性最为敏感。