Finlay J M, Jakubovic A, Fu D S, Fibiger H C
Eur J Pharmacol. 1987 May 7;137(1):117-21. doi: 10.1016/0014-2999(87)90189-0.
Haloperidol increased 3,4-dihydroxyphenylacetic acid and homovanillic acid concentrations in the striatum, nucleus accumbens and olfactory tubercle of both drug-naive rats and rats pretreated with haloperidol (10 injections). The increases in metabolite concentrations were greater in all brain regions of the naive rats, suggesting that haloperidol pretreatment resulted in a decreased responsiveness to the drug (tolerance). However, subchronic haloperidol injections also resulted in decreased basal metabolite concentrations in rats killed 48 h after the last injection. While the response of drug-experienced rats to haloperidol was attenuated relative to that of drug-naive rats, this difference could be accounted for entirely by the decreased basal metabolite concentrations that occur after repeated haloperidol injections.
氟哌啶醇使未用过药的大鼠以及经氟哌啶醇预处理（10次注射）的大鼠纹状体、伏隔核和嗅结节中的3,4-二羟基苯乙酸和高香草酸浓度升高。在未用过药的大鼠的所有脑区中，代谢物浓度的升高幅度更大，这表明氟哌啶醇预处理导致对该药物的反应性降低（耐受性）。然而，亚慢性氟哌啶醇注射也导致在最后一次注射后48小时处死的大鼠中基础代谢物浓度降低。虽然有用药经验的大鼠对氟哌啶醇的反应相对于未用过药的大鼠有所减弱，但这种差异完全可以由反复注射氟哌啶醇后基础代谢物浓度的降低来解释。
