Bierich J R
Monatsschr Kinderheilkd. 1981 Jul;129(7):393-9.
The pubertal growth spurt is based on synergistic effects of hGH and androgenic steroids. It fails to appear in androgen deficiency as well as in complete absence of hGH. Apart from the synergism of biological functions there are interactions with regard to the secretion of hGH and androgens. Investigating the nocturnal hGH-secretion in puberty stage 3 we found twice as high secretion rates as in stage 1. Children with anorchia or constitutional delay of growth and adolescence during treatment with testosterone secreted more than threefold amounts of hGH as before. In two cyproterone acetate-treated adolescents, and in four 12-19 years old patients with hypogonadism, the nocturnal secretion rates of hGH as well as the maximal hGH-peaks attained were lower than in normal prepubertal children. The conclusion is drawn that the androgen-secretion during adolescence is not only prerequisite to the hGH-increment necessary for the pubertal growth spurt but also to the preservation of basal hGH-secretion.
青春期生长突增基于生长激素（hGH）和雄激素类固醇的协同作用。在雄激素缺乏以及完全缺乏hGH的情况下，青春期生长突增不会出现。除了生物学功能的协同作用外，hGH和雄激素的分泌之间也存在相互作用。在青春期3期研究夜间hGH分泌时，我们发现其分泌率是1期的两倍。患有无睾症或生长与青春期体质性延迟的儿童在接受睾酮治疗期间，hGH分泌量是之前的三倍多。在两名接受醋酸环丙孕酮治疗的青少年以及四名12 - 19岁性腺功能减退患者中，hGH的夜间分泌率以及达到的最大hGH峰值均低于正常青春期前儿童。得出的结论是，青春期雄激素分泌不仅是青春期生长突增所需hGH增加的前提条件，也是维持基础hGH分泌的前提条件。
