Van Harreveld A, Reuter J H
Neurosci Lett. 1981 May 29;23(3):329-32. doi: 10.1016/0304-3940(81)90020-3.
Evidence was presented for a glutamate agonistic effect of L-proline which promotes K+-based spreading depressions (SD) in chick retinas at relatively high concentrations (5 mM), in addition to an antagonistic effect which inhibits glutamate-based SDs at lower (2 mM) concentrations. Together these effects explain the observed biphasic effect of L-proline on the incidence of SD in the retina.
有证据表明,L-脯氨酸具有谷氨酸激动作用,在相对高浓度(5 mM)时可促进鸡视网膜中基于钾离子的扩散性抑制(SD),此外,在较低浓度(2 mM)时具有拮抗作用,可抑制基于谷氨酸的SD。这些作用共同解释了观察到的L-脯氨酸对视网膜中SD发生率的双相效应。