L-脯氨酸对鸡视网膜扩展性抑制的双重作用。

The dual effect of L-proline on spreading depression in the chicken retina.

作者信息

Van Harreveld A, Reuter J H

出版信息

Neurosci Lett. 1981 May 29;23(3):329-32. doi: 10.1016/0304-3940(81)90020-3.

Abstract

Evidence was presented for a glutamate agonistic effect of L-proline which promotes K+-based spreading depressions (SD) in chick retinas at relatively high concentrations (5 mM), in addition to an antagonistic effect which inhibits glutamate-based SDs at lower (2 mM) concentrations. Together these effects explain the observed biphasic effect of L-proline on the incidence of SD in the retina.

摘要

有证据表明，L-脯氨酸具有谷氨酸激动作用，在相对高浓度（5 mM）时可促进鸡视网膜中基于钾离子的扩散性抑制（SD），此外，在较低浓度（2 mM）时具有拮抗作用，可抑制基于谷氨酸的SD。这些作用共同解释了观察到的L-脯氨酸对视网膜中SD发生率的双相效应。