Desser-Wiest L
Onkologie. 1981 Jun;4(3):120-36. doi: 10.1159/000214893.
Corticosterone both inhibits cell proliferation in the liver of adult rats and synchronizes division of liver cells after partial hepatectomy. By adrenalectomy, corticosterone can be eliminated from the circulation at least for certain time. Additionally it can be inactivated in the liver cell by competitive inhibition of its cytoplasmatic receptor. Both these procedures lead to an increased cellular proliferation. The influence of these processes on the development of chemically induced liver tumors has been investigated. Animals died significantly earlier from hepatomas, when they had been treated with both diethylnitrosamine and steroids belonging to the group of gestagens, androgens and estrogens (which stimulate proliferation). Therefore, a tumor-promoting effect of these substances can be assumed.
皮质酮既能抑制成年大鼠肝脏中的细胞增殖，又能在部分肝切除术后使肝细胞分裂同步化。通过肾上腺切除术，至少在一定时间内可使循环中的皮质酮消除。此外，它可在肝细胞中通过竞争性抑制其细胞质受体而失活。这两种方法都会导致细胞增殖增加。已经研究了这些过程对化学诱导的肝肿瘤发生发展的影响。当用二乙基亚硝胺和属于孕激素、雄激素和雌激素类（刺激增殖）的类固醇处理动物时，动物死于肝癌的时间明显提前。因此，可以假定这些物质具有促肿瘤作用。
