用 kainic 酸损伤大鼠海马锥体细胞后的运动和探索活动。

The locomotor and exploratory activities in rats after lesion of hippocampal pyramidal cells with kainic acid.

作者信息

Kleinrok Z, Turski L, Wawrzyniak M, Cybaulska R

出版信息

Pol J Pharmacol Pharm. 1980 Sep-Oct;32(5):625-37.

Abstract

The effect of single kainic acid (KA) intracerebroventricular(icv) injection on spontaneous locomotor, exploratory, basal and total activities in rats measured a different times was tested. Whereas at 3 hr after KA icv administration an increase of the total, basal and spontaneous activities of rats were observed, a great decrease of the exploratory activity was noted. KA at 24 hr after its administration depressed all types of rats activities. From 72nd hr after KA icv injection a significant increase in the total, exploratory and spontaneous locomotor activities without changes in the basal activity was observed. The above mentioned changes persisted up to 10-20 days after KA administration. The histological examinations showed evident neuropathologic changes in hippocampal stratum pyramidale. The most evident changes concerned the hippocampal areas CA3/CA4 and CA1. There were observed shrinking, narrowing and fragmentation of pyramidal cells. An intense progressive gliotic reaction was present among the fragmented cells, the layer of pyramidal cells being considerably diminished.

摘要

测试了单次脑室内注射 kainic 酸（KA）对大鼠在不同时间测量的自发运动、探索、基础和总活动的影响。在 KA 脑室内给药后 3 小时，观察到大鼠的总活动、基础活动和自发活动增加，但探索活动明显减少。给药后 24 小时，KA 抑制了大鼠的所有类型活动。在 KA 脑室内注射后 72 小时，观察到总活动、探索活动和自发运动活动显著增加，基础活动无变化。上述变化在 KA 给药后持续 10 - 20 天。组织学检查显示海马锥体细胞层有明显的神经病理变化。最明显的变化涉及海马区域 CA3/CA4 和 CA1。观察到锥体细胞萎缩、变窄和碎片化。在碎片化细胞之间存在强烈的进行性胶质增生反应，锥体细胞层明显减少。