Turski L, Czuczwar S J, Turski W, Kleinrok Z
Methods Find Exp Clin Pharmacol. 1981 Nov-Dec;3(6):361-6.
Rats with bilateral lesions of hippocampal pyramidal cells in the subfield CA 3 with intracerebroventricular kainic acid (0.1 microgram/2 microliter) made more shuttle responses to a buzzer in Pavlovian paradigm, classical conditioning and two-way active avoidance but did not differ remarkably in pseudoconditioning and avoidance conditioning without stimulus pairing, than sham-operated and intact control rats. Animals with unilateral lesion in the CA 3 hippocampal subfield showed no differences in these shuttle situations. The results suggest that CA 3 hippocampal pyramidal cells are of particular importance to the establishment of the stimulus-stimulus relations in the brain.
通过脑室内注射海藻酸（0.1微克/2微升）造成海马CA3亚区双侧锥体细胞损伤的大鼠，在巴甫洛夫范式、经典条件反射和双向主动回避实验中，对蜂鸣声做出的穿梭反应比假手术组和完整对照组大鼠更多，但在伪条件反射和无刺激配对的回避条件反射中差异不显著。海马CA3亚区单侧损伤的动物在这些穿梭实验中没有差异。结果表明，海马CA3锥体细胞对大脑中刺激-刺激关系的建立尤为重要。
