Ortmann R, Martin S, Waldmeier P C
Psychopharmacology (Berl). 1981;74(2):109-14. doi: 10.1007/BF00432674.
The behavioral syndrome induced by L-5-hydroxytryptophan (L-5-HTP) in rats was used to study the supersensitivity to L-5-HTP and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) which develops after unilateral intracerebroventricular (ICV) injections of 200 microgram 5,7-dihydroxytryptamine (5,7-DHT). Pretreatment of the animals with a combination of desipramine and nomifensine was found to protect dopamine neurones better than desipramine alone. Maximal behavioral supersensitivity to L-5-HTP and 5-MeODMT was found as early as 24 h after injection of the neurotoxin, even in the presence of the specific 5-HT uptake inhibitor CGP 6085 A, or the MAO-A inhibitor clorgyline. The results indicate that a quickly occurring postsynaptic event contributes to the development of behavioral supersensitivity after ICV injections of 5,7-DHT.
利用L-5-羟色氨酸（L-5-HTP）诱导大鼠产生的行为综合征，研究单侧脑室内（ICV）注射200微克5,7-二羟基色胺（5,7-DHT）后对L-5-HTP和5-甲氧基-N,N-二甲基色胺（5-MeODMT）产生的超敏反应。结果发现，用去甲丙咪嗪和诺米芬辛联合预处理动物，比单独使用去甲丙咪嗪能更好地保护多巴胺神经元。即使存在特异性5-羟色胺摄取抑制剂CGP 6085 A或单胺氧化酶-A抑制剂氯吉兰，在注射神经毒素后最早24小时就发现了对L-5-HTP和5-MeODMT的最大行为超敏反应。结果表明，快速发生的突触后事件有助于ICV注射5,7-DHT后行为超敏反应的发展。
