Browne R G
Psychopharmacology (Berl). 1981;74(3):245-9. doi: 10.1007/BF00427103.
Male Sprague-Dawley rats were trained to discriminate 3.2 mg/kg yohimbine HCl from saline in a two-lever operant procedure. Generalization tests indicated that piperoxane, another alpha 2-adrenergic blocker with anxiogenic properties in humans, produces yohimbine-like discriminati-effects.. In contrast to yohimbine and piperoxane, many other agents were discriminated as vehicle, including corynanthine, raubasine, phentolamine, prazosin, WB-4101, mianserin, tolazoline, and mezilamine. Diazepam caused a dose-related antagonism of yohimbine's stimulus properties. A partial antagonism of yohimbine cueing was also obtained with meprobamate, phenobarbital, chlordiazepoxide, and clonazepam. These results suggest that yohimbine discrimination in rats may be a useful model for detecting agents with anxiolytic activity.
雄性斯普拉格-道利大鼠在双杠杆操作性条件反射程序中接受训练，以区分3.2毫克/千克盐酸育亨宾和生理盐水。泛化试验表明，哌罗克生是另一种在人类中具有致焦虑特性的α2肾上腺素能阻滞剂，可产生类似育亨宾的辨别效应。与育亨宾和哌罗克生不同，许多其他药物被辨别为溶媒，包括柯楠碱、萝巴新、酚妥拉明、哌唑嗪、WB-4101、米安色林、妥拉唑啉和美齐拉明。地西泮引起了与剂量相关的对育亨宾刺激特性的拮抗作用。眠尔通、苯巴比妥、氯氮卓和氯硝西泮也对育亨宾提示产生了部分拮抗作用。这些结果表明，大鼠中的育亨宾辨别可能是检测具有抗焦虑活性药物的有用模型。
