Boulard G, Cazenave J, Varene N, Brachet-Liermain A
Ann Anesthesiol Fr. 1981;22(2):185-90.
Six samples of ventricular cerebral spinal fluid from an external ventricular drain, and peripheral venous blood were taken during the course of parenteral diazepam administration in man. The diazepam level was measured by gas phase chromatography. The levels of diazepam in the CSF were low compared with the plasms concentrations and around the same level as the free circulating fraction. The drug appears in the CSF relatively late after intravenous administration. It would appear that the passage of the drug from the blood into the CSF is slow and not very marked. Therefore it is not the main cause for the pharmocodynamic effects which are the result of the drug passing the blood barrier in the more restricted sense.
在人体静脉注射地西泮过程中，采集了6份来自外部脑室引流管的脑室脑脊液样本以及外周静脉血样本。通过气相色谱法测定地西泮水平。与血浆浓度相比，脑脊液中的地西泮水平较低，且与游离循环部分的水平大致相同。静脉给药后，药物在脑脊液中出现相对较晚。药物从血液进入脑脊液的过程似乎缓慢且不太显著。因此，它不是药物在更严格意义上通过血脑屏障所产生的药效学作用的主要原因。
