Effects of the neuroexcitatory amino acids aspartate and glutamate on LH secretion.

The effects of infusing aspartate or glutamate into the third ventricle of unanesthetized female animals was examined. LH levels were significantly enhanced within 5-15 min following aspartate (0.5 and 0.2 micromoles), separated by one hour and twenty-four hours, promoted consecutive increases in plasma LH. Plasma FSH levels, however, were not altered in any of the animals examined. This study further supports the findings that neuroexcitatory amino acids promote LH secretion.