一种强效且特异性的β2-肾上腺素能受体拮抗剂对眼压的影响。
Effects of a potent and specific beta 2-adrenoceptor antagonist on intraocular pressure.
作者信息
Nathanson J A
出版信息
Br J Pharmacol. 1981 May;73(1):97-100. doi: 10.1111/j.1476-5381.1981.tb16776.x.
Abstract
1 Physiological studies support the possibility of adrenergic regulation of aqueous humor secretion from the ciliary process, a tissue which has recently been shown to contain a predominance of beta 2-adrenoceptors. 2 The present experiments examine the effects of a potent and highly specific beta 2-antagonist (IPS 339) on intraocular pressure in the normal rabbit eye. 3 The observed decrease in pressure caused by IPS 339 suggests that highly specific beta 2-antagonists may be useful in decreasing elevated intraocular pressure.
摘要
- 生理学研究支持睫状体房水分泌受肾上腺素能调节的可能性，最近已证明该组织中β2 -肾上腺素能受体占主导。2. 本实验研究了一种强效且高度特异性的β2拮抗剂（IPS 339）对正常兔眼眼压的影响。3. 观察到IPS 339引起的眼压降低表明，高度特异性的β2拮抗剂可能有助于降低升高的眼压。
相似文献
1
Effects of a potent and specific beta 2-adrenoceptor antagonist on intraocular pressure.一种强效且特异性的β2-肾上腺素能受体拮抗剂对眼压的影响。
Br J Pharmacol. 1981 May;73(1):97-100. doi: 10.1111/j.1476-5381.1981.tb16776.x.
2
ICI 118,551: an effective ocular hypotensive agent with selectivity for the ciliary process beta 2-adrenoceptor and with minimal cardiac side effects.ICI 118,551：一种有效的降眼压药物，对睫状突β2肾上腺素能受体具有选择性，且心脏副作用极小。
Br J Pharmacol. 1984 Nov;83(3):821-9. doi: 10.1111/j.1476-5381.1984.tb16238.x.
3
Biochemical and physiological effects of S-32-468, a beta-adrenoceptor antagonist with possible oculoselectivity.S-32-468（一种可能具有眼选择性的β-肾上腺素能受体拮抗剂）的生化和生理效应
Curr Eye Res. 1985 Mar;4(3):191-7. doi: 10.3109/02713688509000850.
4
Beta adrenergic effects on ciliary epithelial permeability, aqueous humor formation and pseudofacility in the normal and sympathectomized rabbit eye.β肾上腺素能对正常及交感神经切除兔眼睫状上皮通透性、房水生成及假性引流率的影响。
Curr Eye Res. 1981;1(7):419-23. doi: 10.3109/02713688109019980.
5
Effects of the R(+)- and S(-)-isomers of beta-adrenoceptor blockers with intrinsic sympathomimetic activity, befunolol and carteolol, on rabbit intraocular pressure.具有内在拟交感活性的β-肾上腺素能受体阻滞剂R(+)-和S(-)-异构体，倍他洛尔和卡替洛尔对兔眼压的影响。
Can J Physiol Pharmacol. 1991 Aug;69(8):1243-5. doi: 10.1139/y91-182.
6
Are beta-adrenergic mechanisms involved in ocular hypotensive actions of adrenergic drugs?β-肾上腺素能机制是否参与了肾上腺素能药物的眼压降低作用？
Ophthalmic Res. 1985;17(1):49-53. doi: 10.1159/000265349.
7
Pharmacological effects of topical timolol in the rabbit eye.噻吗洛尔滴眼液对兔眼的药理作用。
Invest Ophthalmol Vis Sci. 1980 Oct;19(10):1189-97.
8
[Morphological changes in the ciliary epithelium after instillation of 1% befunolol (beta-adrenergic blocker)].[滴入1%倍他洛尔（β-肾上腺素能阻滞剂）后睫状上皮的形态学变化]
Nippon Ganka Gakkai Zasshi. 1984 Feb;88(2):251-65.
9
[Mechanism of action of beta-blockers].[β受体阻滞剂的作用机制]
Ophtalmologie. 1990 Mar-Apr;4(2):154-5.
引用本文的文献
1
Adrenoceptors in the Eye - Physiological and Pathophysiological Relevance.眼部肾上腺素能受体——生理与病理生理学相关性。
Handb Exp Pharmacol. 2024;285:453-505. doi: 10.1007/164_2023_702.
2
β-Adrenoreceptors as Therapeutic Targets for Ocular Tumors and Other Eye Diseases-Historical Aspects and Nowadays Understanding.β-肾上腺素能受体作为眼部肿瘤和其他眼病的治疗靶点：历史方面和现今的认识。
Int J Mol Sci. 2023 Feb 28;24(5):4698. doi: 10.3390/ijms24054698.
3
Beta adrenergic receptors in pigmented ciliary processes.色素性睫状突中的β肾上腺素能受体。
Br J Ophthalmol. 1982 Dec;66(12):788-92. doi: 10.1136/bjo.66.12.788.
4
ICI 118,551: an effective ocular hypotensive agent with selectivity for the ciliary process beta 2-adrenoceptor and with minimal cardiac side effects.ICI 118,551：一种有效的降眼压药物，对睫状突β2肾上腺素能受体具有选择性，且心脏副作用极小。
Br J Pharmacol. 1984 Nov;83(3):821-9. doi: 10.1111/j.1476-5381.1984.tb16238.x.
5
Beta-adrenergic receptor subtypes in iris-ciliary body of rabbits.兔虹膜睫状体中的β-肾上腺素能受体亚型
Graefes Arch Clin Exp Ophthalmol. 1984;221(4):167-70. doi: 10.1007/BF02134259.
6
beta-Adrenergic receptor subtypes and intraocular pressure.β-肾上腺素能受体亚型与眼压
Br J Ophthalmol. 1983 Aug;67(8):557-8. doi: 10.1136/bjo.67.8.557.
7
The role of beta 2-adrenoceptors in the IOP-lowering effect of adrenaline.β2肾上腺素能受体在肾上腺素降低眼压作用中的角色。
Graefes Arch Clin Exp Ophthalmol. 1982;218(6):297-300. doi: 10.1007/BF02150442.
8
Neodymium-YAG transscleral cyclocoagulation in rabbit eyes.兔眼钕钇铝石榴石经巩膜睫状体光凝术
Br J Ophthalmol. 1987 Jun;71(6):441-4. doi: 10.1136/bjo.71.6.441.
本文引用的文献
1
Adrenergic regulation of intraocular pressure: identification of beta 2-adrenergic-stimulated adenylate cyclase in ciliary process epithelium.眼内压的肾上腺素能调节：睫状体上皮细胞中β2-肾上腺素能刺激的腺苷酸环化酶的鉴定。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7420-4. doi: 10.1073/pnas.77.12.7420.
2
Beta-adrenergic receptors in ciliary processes of the rabbit.兔睫状突中的β-肾上腺素能受体
Invest Ophthalmol Vis Sci. 1980 Feb;19(2):203-7.
3
Adrenergic drugs and intraocular pressure: suppression of ocular hypertension induced by water loading.肾上腺素能药物与眼压：对水负荷诱导的高眼压的抑制作用
Exp Eye Res. 1980 Jan;30(1):93-104. doi: 10.1016/0014-4835(80)90127-x.
4
Effects of catecholamines on the ocular tension of normal and sympathetically denervated rabbit eyes.儿茶酚胺对正常及交感神经去神经支配兔眼眼压的影响。
Exp Eye Res. 1971 Jul;12(1):13-24. doi: 10.1016/0014-4835(71)90123-0.
5
Beta-adrenergic responses in the eyes of rabbits, primates, and man.兔子、灵长类动物和人类眼睛中的β-肾上腺素能反应。
Exp Eye Res. 1974 Sep;19(3):281-95. doi: 10.1016/0014-4835(74)90147-x.
6
Some characteristics of an adenyl cyclase preparation from rabbit ciliary process tissue.兔睫状体组织腺苷酸环化酶制剂的一些特性
Exp Eye Res. 1971 Jul;12(1):99-111. doi: 10.1016/0014-4835(71)90134-5.
7
Drug therapy of glaucoma.青光眼的药物治疗。
Br J Ophthalmol. 1972 Mar;56(3):288-94. doi: 10.1136/bjo.56.3.288.
8
Comparison of beta adrenergic receptor subtypes in mammalian tissues.哺乳动物组织中β肾上腺素能受体亚型的比较。
J Pharmacol Exp Ther. 1979 Dec;211(3):502-8.
9
Experimental studies on the mechanism of action of timolol.噻吗洛尔作用机制的实验研究
Surv Ophthalmol. 1979 May-Jun;23(6):363-70. doi: 10.1016/0039-6257(79)90229-7.
10
In vitro determination of the ability of drugs to bind to adrenergic receptors.药物与肾上腺素能受体结合能力的体外测定。
Invest Ophthalmol Vis Sci. 1977 Dec;16(12):1118-24.
Zotero 插件