[L-抗坏血酸和D-异抗坏血酸对大鼠肝脏中酪氨酸转氨酶诱导形成的影响]
[Effect of L-ascorbic and D-isoascorbic acids on induced formation of tyrosine aminotransferase in rat liver].
作者信息
Levchuk A A, Bukin Iu V, Smirnova K D, Raushenbakh M O, Rubtsov I A
出版信息
Vopr Med Khim. 1981;27(4):500-3.
PMID:6117152
Abstract
Administration of ascorbic acid at moderate doses/0.05-0.1 g per kg of body mass/was shown to induce tyrosine transaminase in liver tissue of intact rats. The enzyme induction depended on the state of adrenal glands and was inhibited by actinomycin D. As distinct from the native form of L-ascorbic acid moderate doses of D-isoascorbic acid did not induce the enzyme in rat liver tissue; these data suggest the relative biological inactivity of D-isoascorbic acid.
摘要
以中等剂量/每千克体重0.05 - 0.1克/施用抗坏血酸，已表明可诱导正常大鼠肝组织中的酪氨酸转氨酶。该酶的诱导取决于肾上腺的状态，并受到放线菌素D的抑制。与天然形式的L - 抗坏血酸不同，中等剂量的D - 异抗坏血酸不会在大鼠肝组织中诱导该酶；这些数据表明D - 异抗坏血酸相对无生物学活性。
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