Marveeva A A, Valueva I M, Bukin Y V
Vopr Med Khim. 1975 May-Jun;21(3):272-6.
In a period of lowest day activity of tyrosine aminotransferase, within 6-8 days after bilatheral adrenalectomy, the enzyme activity was decreased by about 20% as compared with an adequate control. At the same time, within a day and seven days after hypophisectomy, in rat liver tissue the enzyme activity was increased, approximately two-fold as compared with the normal state. Within four hrs after intraperitoneal administration into intact fasting rats at a dose of 2-2.5 g per 1 kg of body weight D-cycloserine and its dimer caused an induction of tyrosine aminotransferase by 75% and 180%, respectively. Induction of the enzyme by D-cycloserine and its dimer was inhibited by actinomycin D; the phenomenon was not observed in adrenalectomized rats. Within a day after hypophisectomy D-cycloserine did not cause the induction of tyrosine aminotransferase in rat liver tissue; to the contrary, the dimer of D-cycloserine caused induction of the enzyme, comparable to the ACTH effect, in liver tissue of hypophisectomized rats.
在酪氨酸转氨酶日活性最低的时期，双侧肾上腺切除术后6 - 8天内，与适当的对照组相比，该酶活性降低了约20%。同时，垂体切除术后1天至7天内，大鼠肝脏组织中的酶活性增加，与正常状态相比约增加了两倍。在给禁食的完整大鼠腹腔注射剂量为每1千克体重2 - 2.5克的D - 环丝氨酸及其二聚体后4小时内，酪氨酸转氨酶的诱导率分别为75%和180%。放线菌素D抑制了D - 环丝氨酸及其二聚体对该酶的诱导作用；在肾上腺切除的大鼠中未观察到这种现象。垂体切除术后1天内，D - 环丝氨酸未引起大鼠肝脏组织中酪氨酸转氨酶的诱导；相反，D - 环丝氨酸二聚体在垂体切除大鼠的肝脏组织中引起了该酶的诱导，与促肾上腺皮质激素的作用相当。
