Gryglewski R J, Szczeklik A, Zygulska-Mach H, Kostka-Trabka E
Philos Trans R Soc Lond B Biol Sci. 1981 Aug 18;294(1072):383-8. doi: 10.1098/rstb.1981.0114.
We hypothesize that prostacyclin (PGI2) is an anti-atherosclerotic hormone and that atherosclerosis develops when endothelial PGI2 synthetase is inhibited by lipid peroxides. Serum lipid peroxides occur in low-density lipoproteins (LDL). LDL lipid peroxides are elevated in common types of hyperlipoproteinaemias, PGI2 generation is impaired in atherosclerosis, and infusion of synthetic PGI2 into patients alleviates symptoms resulting from arteriosclerosis obliterans, central retinal vein occlusion or spontaneous angina.
我们推测前列环素（PGI2）是一种抗动脉粥样硬化激素，当内皮前列环素合成酶被脂质过氧化物抑制时，动脉粥样硬化就会发生。血清脂质过氧化物存在于低密度脂蛋白（LDL）中。在常见类型的高脂蛋白血症中，LDL脂质过氧化物会升高，在动脉粥样硬化中PGI2生成受损，向患者输注合成PGI2可缓解因闭塞性动脉硬化、视网膜中央静脉阻塞或自发性心绞痛引起的症状。
