低密度脂蛋白（LDL）是脂质过氧化物的载体，并抑制动脉中前列环素（PGI2）的生物合成。
Low density lipoproteins (LDL) are carriers for lipid peroxides and inhibit prostacyclin (PGI2) biosynthesis in arteries.
作者信息
Szczeklik A, Gryglewski R J
出版信息
Artery. 1980;7(6):488-95.
PMID:7016082
Abstract
Serum lipid peroxides are concentrated in the LDL fraction. HDL and plasma proteins quench the interaction of LDL lipid peroxides with thiobarbituric acid. LDL inhibits prostacyclin biosynthesis both in incubated rat aortic slices and superfused bovine coronary arteries. It is proposed that atherogenic properties of LDL are associated with inactivation of arterial prostacyclin synthetase by lipid peroxides which are present in LDL.
摘要
血清脂质过氧化物集中在低密度脂蛋白（LDL）部分。高密度脂蛋白（HDL）和血浆蛋白可抑制LDL脂质过氧化物与硫代巴比妥酸的相互作用。LDL在孵育的大鼠主动脉切片和灌注的牛冠状动脉中均抑制前列环素的生物合成。有人提出，LDL的致动脉粥样硬化特性与LDL中存在的脂质过氧化物使动脉前列环素合成酶失活有关。
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