Gabbert H, Wagner R, Höhn P, Kern O, Wanitschke R
Virchows Arch B Cell Pathol Incl Mol Pathol. 1981;37(3):285-96.
In rats a severe but compensated chronic renal insufficiency was induced by stepwise 9/10 nephrectomy. Despite this severe chronic renal insufficiency we observed no relevant pathological changes in the intestinal mucosa. In particular, we found no evidence of mucosal erosions, ulceration or pseudomembranous colitis, findings which are traditionally thought to be characteristic of the uremic state. This was also true of those animals dying prematurely from uremia. Thus serious doubts arise about the existence of "uremic enterocolitis", doubts which also proved justified after a critical review of the literature on human pathology.
通过逐步切除9/10的肾脏，在大鼠中诱导出严重但代偿性的慢性肾功能不全。尽管存在这种严重的慢性肾功能不全，但我们在肠黏膜中未观察到相关的病理变化。特别是，我们没有发现黏膜糜烂、溃疡或假膜性结肠炎的证据，而这些发现传统上被认为是尿毒症状态的特征。那些因尿毒症过早死亡的动物也是如此。因此，对于“尿毒症性小肠结肠炎”的存在产生了严重怀疑，在对人类病理学文献进行批判性回顾后，这些怀疑也被证明是合理的。
