Klei T R, Enright F M, Blanchard D P, Uhl S A
Acta Trop. 1981 Sep;38(3):267-76.
Two types of experiments were used to study the degree of tissue responsiveness which occurred in Brugia pahangi-infected jirds. In experiment 1, the severity of lymphatic lesions which developed following subcutaneous infection of jirds which has existing intraperitoneal infections was compared to the severity of lymphatic lesions that developed following subcutaneous infection of jirds without previous infections. In experiment 2, comparisons were made of the sizes of granulomas which formed in the lungs around cyanogen bromide-activated Sepharose 4B beads coupled with B. pahangi antigen, which were inoculated intravenously into jirds which: 1. had existing lymphatic infections; 2. were uninfected. Results of both experiments indicated that jirds with intraperitoneal or lymphatic infections of B. pahangi of 120 to 160 days duration were significantly less responsive to B. pahangi or B. pahangi antigens as measured by pathologic tissue reactions than were uninfected jirds. The sizes of granulomas which formed around beads coupled to B. pahangi antigen in noninfected and nonsensitized jirds suggest that this worm material may contain factors which nonspecifically enhance the granulomatous inflammatory reaction.
采用两种类型的实验来研究感染彭亨布鲁线虫的沙鼠体内发生的组织反应程度。在实验1中，将已有腹腔感染的沙鼠经皮下感染后出现的淋巴病变严重程度，与未感染过的沙鼠经皮下感染后出现的淋巴病变严重程度进行比较。在实验2中，比较了静脉接种与彭亨布鲁线虫抗原偶联的溴化氰活化琼脂糖4B珠后，在肺部形成的肉芽肿大小，这些沙鼠分为两组：1. 已有淋巴感染；2. 未感染。两个实验的结果均表明，感染彭亨布鲁线虫120至160天的腹腔或淋巴感染沙鼠，通过病理组织反应测量，对彭亨布鲁线虫或其抗原的反应明显低于未感染的沙鼠。在未感染且未致敏的沙鼠中，与彭亨布鲁线虫抗原偶联的珠子周围形成的肉芽肿大小表明，这种蠕虫物质可能含有非特异性增强肉芽肿性炎症反应的因子。
