Bauer K
Int J Pept Protein Res. 1976;8(5):417-26. doi: 10.1111/j.1399-3011.1976.tb02521.x.
In a continuation of earlier studies the connection between a reconstructed ancestral histone IV peptide and various sequences from non-histone proteins was investigated. This peptide, AHAP, was found to be related to partial peptides from the human encephalitogenic protein, immunoglobulin L-chains, fibrinopeptide A, glyceraldehyde-3-phosphate-dehydrogenase, TMV coat protein and several other proteins and protein families; for comparison, nodal sequences were employed wherever possible. The widespread occurrence of genetic information expressed in AHAP caused us to rename the peptide PGI-FI (primordial genetic information-fragment 1) since this peptide is apparently part of a very primitive and ancient genetic information, and may be called "protogene".
在早期研究的后续工作中，对一种重构的祖先组蛋白IV肽与来自非组蛋白的各种序列之间的联系进行了研究。发现这种肽AHAP与来自人致脑炎蛋白、免疫球蛋白L链、纤维蛋白肽A、甘油醛-3-磷酸脱氢酶、烟草花叶病毒外壳蛋白以及其他几种蛋白质和蛋白质家族的部分肽相关；为作比较，尽可能采用了节点序列。AHAP中表达的遗传信息广泛存在，这使我们将该肽重新命名为PGI-FI（原始遗传信息片段1），因为这种肽显然是非常原始和古老的遗传信息的一部分，可被称为“原基因”。
