Andersson K, Eneroth P, Agnati L F
Acta Physiol Scand. 1981 Oct;113(2):227-31. doi: 10.1111/j.1748-1716.1981.tb06887.x.
The effects of acute single doses (0.3 and 1 mg/kg) of nicotine on various hypothalamic catecholamine nerve terminal systems and on the secretion of adenohypophyseal hormones in the rat were studied. Nicotine, in a dose of 1.0 mg/kg, increased noradrenaline turnover in the median eminence and in the peri- and paraventricular hypothalamic regions. The dopamine and noradrenaline nerve terminal systems in the median eminence and the dorsomedial hypothalamic nucleus respectively were unaffected. Serum GH levels were decreased and serum prolactin levels increased after a dose of 1 mg/kg. In the presence of tyrosine hydroxylase inhibition, nicotine in a dose of 1 mg/kg, instead increased GH and also LH secretion. It is suggested that the preferential increases of noradrenaline turnover in various hypothalamic noradrenaline nerve terminal systems by nicotine may be partly responsible for the nicotine induced increases of serum prolactin. GH and LH levels observed.
研究了急性单次给予尼古丁（0.3和1mg/kg）对大鼠各种下丘脑儿茶酚胺神经末梢系统以及腺垂体激素分泌的影响。剂量为1.0mg/kg的尼古丁增加了正中隆起以及下丘脑室周和室旁区域的去甲肾上腺素周转率。正中隆起和下丘脑背内侧核中的多巴胺和去甲肾上腺素神经末梢系统未受影响。给予1mg/kg剂量后，血清生长激素水平降低，血清催乳素水平升高。在存在酪氨酸羟化酶抑制的情况下，1mg/kg剂量的尼古丁反而增加了生长激素以及促黄体生成素的分泌。提示尼古丁使各种下丘脑去甲肾上腺素神经末梢系统中的去甲肾上腺素周转率优先增加，可能部分导致了尼古丁诱导的血清催乳素、生长激素和促黄体生成素水平升高。
