Center for Reproductive Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Aging (Albany NY). 2021 Feb 1;13(4):5226-5237. doi: 10.18632/aging.202442.
Few studies have investigated whether associations between smoking, sex hormone levels, and symptoms of late-onset hypogonadism (LOH) in men are affected by age. This multi-center, cross-sectional study involving 6,296 men aged 40-79 years was conducted between June 1, 2013 and August 31, 2016 in 6 provinces of China. Total testosterone, free testosterone, and Aging Males' Symptoms scale (AMS) scores were compared depending on smoking status and the number of cigarettes smoked. Total testosterone was higher in smokers than in non-smokers in all except the 70-79 year old subgroup. Free testosterone was higher in smokers than non-smokers for the 40-49 and 50-59 year old subgroups, but not the 60-69 and 70-79 year old subgroups. Total testosterone was positively associated with number of cigarettes consumed in smokers aged 40-49 and 50-59 years. Sexual and somatic AMS scores were higher in current and ex-smokers than in non-smokers in all age subgroups from 40 to 79 years and were negatively associated with cigarette consumption in smokers aged 40-49 years. These results indicate that, as men age, the positive association between smoking and testosterone weakens, while the positive association between smoking and LOH symptoms becomes stronger.
很少有研究调查吸烟、性激素水平与男性迟发性性腺功能减退症（LOH）症状之间的关联是否受年龄影响。本多中心、横断面研究于 2013 年 6 月 1 日至 2016 年 8 月 31 日在中国 6 个省进行，共纳入 6296 名年龄在 40-79 岁的男性。根据吸烟状况和吸烟数量比较总睾酮、游离睾酮和男性老龄化症状量表（AMS）评分。除 70-79 岁年龄组外，所有年龄组中吸烟者的总睾酮均高于不吸烟者。40-49 岁和 50-59 岁年龄组吸烟者的游离睾酮高于不吸烟者，但 60-69 岁和 70-79 岁年龄组吸烟者则不然。40-49 岁和 50-59 岁吸烟男性的总睾酮与吸烟数量呈正相关。在 40-79 岁所有年龄组中，当前吸烟者和戒烟者的性和躯体 AMS 评分均高于不吸烟者，且 40-49 岁吸烟男性的 AMS 评分与吸烟数量呈负相关。这些结果表明，随着年龄的增长，吸烟与睾酮之间的正相关性减弱，而吸烟与 LOH 症状之间的正相关性增强。
