Paladugu R R, Nathwani B N, Goodstein J, Dardi L E, Memoli V E, Gould V E
Cancer. 1982 Jan 15;49(2):343-9. doi: 10.1002/1097-0142(19820115)49:2<343::aid-cncr2820490222>3.0.co;2-t.
Primary neuroendocrine tumors of the larynx appear to be extremely rare. We report a case of well-differentiated neuroendocrine carcinoma arising in the larynx of a 61-year-old white woman. This case was initially diagnosed as a lymph node metastasis in the neck from an unknown primary carcinoma. Extensive workup subsequently revealed that the larynx was the primary site of the tumor. An electron microscopic study of both the primary and metastatic tumors showed numerous neurosecretory-type granules. Immunohistochemical studies revealed positive immunoreactivity against calcitonin, somatostatin, and ACTH. However, the tumor also displayed focal exocrine differentiation and mucosubstance production. The patient underwent a supraglottic laryngectomy and radical neck dissection and was free of tumor 22 months postoperatively.
喉原发性神经内分泌肿瘤似乎极为罕见。我们报告一例发生于一名61岁白人女性喉部的高分化神经内分泌癌。该病例最初被诊断为颈部淋巴结转移癌，原发癌部位不明。随后的全面检查显示喉部是肿瘤的原发部位。对原发肿瘤和转移肿瘤的电子显微镜研究显示有大量神经分泌型颗粒。免疫组织化学研究显示对降钙素、生长抑素和促肾上腺皮质激素呈阳性免疫反应。然而，肿瘤也表现出局灶性外分泌分化和黏液物质产生。患者接受了声门上喉切除术和根治性颈清扫术，术后22个月无肿瘤复发。
