Kirkeby S
Histochem J. 1976 Sep;8(5):463-70. doi: 10.1007/BF01003836.
Miscellaneous metal cations and EDTA have been used as activators and inhibitors of esterase activity in the thyroid of the guinea-pig. The results indicate that the 5-bromoiondoxyl acetate esterase in the epithelial cells probably consists of two different A-esterase isoenzymes, one present in group I cells (the para-, intra-, and inter-follicular cells) and the other in group II cells (the follicular cells proper). The first isoenzyme seems to be calcium-dependent whereas the other is activated by various metal ions. Ca2+ + Mn2+ and Ca2+ + Co2+ were found to activate the esterase activity in group I cells. EDTA and Mn2+, on the other hand, activated the esterase activity in group II cells.
多种金属阳离子和乙二胺四乙酸（EDTA）已被用作豚鼠甲状腺中酯酶活性的激活剂和抑制剂。结果表明，上皮细胞中的5-溴吲哚酚乙酸酯酶可能由两种不同的A酯酶同工酶组成，一种存在于I组细胞（滤泡旁细胞、滤泡内细胞和滤泡间细胞）中，另一种存在于II组细胞（真正的滤泡细胞）中。第一种同工酶似乎依赖于钙，而另一种则被各种金属离子激活。发现Ca2+ + Mn2+和Ca2+ + Co2+可激活I组细胞中的酯酶活性。另一方面，EDTA和Mn2+可激活II组细胞中的酯酶活性。
