Kirkeby S
Virchows Arch B Cell Pathol. 1977 Feb 8;23(2):129-36. doi: 10.1007/BF02889125.
By use of different activators and inhibitors, TOCP(tri-o-cresyl phosphate), PCMB (parachloromercury benzoate), NiCl2, Pb(NO3)2, HgCl2, Hg(NO3)2, eserine and sodium taurocholate, it is shown that the esterase in the cyst cells and in group I cells of the guinea pig thyroid probably are A-esterase isoenzymes. The activity in the majority of cyst cells is considerably stronger than in the other thyroid epithelial cells, and it is resistant to Hg inactivation. Neither esterase type nor intensity of the reaction product is altered in group I-II or cyst cells during vitamin A-deficiency. When a normal diet is given, the esterase in all thyroid epithelial cells is very sensitive to sodium taurocholate, while in cyst cells it is rather resistant to this inhibitor at vitamin-A-deficiency.
通过使用不同的激活剂和抑制剂，如磷酸三邻甲苯酯（TOCP）、对氯汞苯甲酸（PCMB）、氯化镍（NiCl₂）、硝酸铅（Pb(NO₃)₂）、氯化汞（HgCl₂）、硝酸汞（Hg(NO₃)₂）、毒扁豆碱和牛磺胆酸钠，结果表明豚鼠甲状腺囊肿细胞和I组细胞中的酯酶可能是A-酯酶同工酶。大多数囊肿细胞中的活性明显强于其他甲状腺上皮细胞，并且它对汞失活具有抗性。在维生素A缺乏期间，I-II组或囊肿细胞中的酯酶类型和反应产物强度均未改变。当给予正常饮食时，所有甲状腺上皮细胞中的酯酶对牛磺胆酸钠非常敏感，而在囊肿细胞中，在维生素A缺乏时它对这种抑制剂相当耐受。
