Schwab W, zum Winkel K, Ammon J
HNO. 1976 Sep;24(9):301-5.
Increased tumor radiosensitivity can be achieved by the technique of synchronisation, although as yet this relationship has only been partial. Our clinical experiences from 1970-1974 with this technique lead to the following considerations: 1. Synchronized radiotherapy (Telecobalt) is administered twice weekly, independent of adjunctive medications (such as fluoro-uracil, vincristin or bleomycin). 2. Synchronized radiotherapy does not change previous indications for operative intervention. 3. The described technique permits successful treatment of advanced tumors as well as postoperative tumor recurrences of recurrences in previously-irradiated tisssues. 4. The radiosensitivity of poorly oxygenated tumor tissues may be increased. 5. Radiation dosage must not be reduced. 6. Distant tumor metastases can also be treated with additional chemotherapy (as synchronized chemotherapy).
通过同步技术可以提高肿瘤的放射敏感性，尽管迄今为止这种关系还只是部分成立。我们在1970年至1974年期间使用该技术的临床经验引发了以下思考：1. 同步放疗（钴远距离治疗）每周进行两次，与辅助药物（如氟尿嘧啶、长春新碱或博来霉素）无关。2. 同步放疗不会改变先前手术干预的指征。3. 所描述的技术允许成功治疗晚期肿瘤以及先前照射组织中的术后肿瘤复发。4. 低氧肿瘤组织的放射敏感性可能会提高。5. 放射剂量不得降低。6. 远处肿瘤转移也可以用额外的化疗（作为同步化疗）进行治疗。
