Neal M J, Cunningham J R, James T A, Joseph M, Collins J F
Neurosci Lett. 1981 Nov 4;26(3):301-5. doi: 10.1016/0304-3940(81)90149-x.
The light-evoked release of acetylcholine (ACh) from the rabbit retina was taken as a measure of cholinergic amacrine cell activity. The glutamate analogue DL-(+/-)-2-amino-4-phosphonobutyric acid (APB) prevented the light-evoked release of ACh and also selectively abolished the ON-responses of ganglion cells and the ERG b-wave. It is concluded that the input to cholinergic amacrine cells involves mainly the depolarizing bipolar cells, which subserve ON-channels. L-(+)-stereoisomer of APB was 15 times more potent than the D-(-)-isomer in suppressing ACh release and the b-wave, suggesting that the mechanism of action of APB does not involve antagonism of excitatory amino acids.
兔视网膜中光诱发的乙酰胆碱（ACh）释放被用作胆碱能无长突细胞活性的一种衡量指标。谷氨酸类似物DL-(+/-)-2-氨基-4-膦酰丁酸（APB）可阻止光诱发的ACh释放，并且还选择性地消除了神经节细胞的ON反应和视网膜电图b波。得出的结论是，胆碱能无长突细胞的输入主要涉及去极化双极细胞，这些双极细胞为ON通道提供支持。APB的L-(+)-立体异构体在抑制ACh释放和b波方面的效力比D-(-)-异构体强15倍，这表明APB的作用机制不涉及对兴奋性氨基酸的拮抗作用。
