Edwards C R, Yeo T, Delitala G, Al Dujaili E A, Boscaro M, Besser G M
Scand J Gastroenterol Suppl. 1981 Jun;69:75-9.
The effects of ranitidine on anterior pituitary and adrenal function have been studied using isolated perfused rat anterior pituitary and zona glomerulosa cells. Ranitidine did not have pituitary hormone releasing activity with respect to LH, TSH, GH and ACTH. It also did not alter prolactin secretion in experiments designed to test whether it acted as a dopamine agonist or antagonist. In the adrenal cell studies ranitidine infusion stimulated basal aldosterone secretion and inhibited the release of aldosterone in response to angiotensin II, but not to ACTH. These experiments suggest that ranitidine is unlikely to alter pituitary hormone secretion by a direct action on the pituitary. The drug, however, can affect aldosterone secretion in vitro and further in vivo studies are required to elucidate the significance of this.
已使用离体灌流的大鼠垂体前叶和肾小球带细胞研究了雷尼替丁对垂体前叶和肾上腺功能的影响。雷尼替丁对促黄体生成素（LH）、促甲状腺激素（TSH）、生长激素（GH）和促肾上腺皮质激素（ACTH）没有垂体激素释放活性。在旨在测试其作为多巴胺激动剂或拮抗剂作用的实验中，它也没有改变催乳素的分泌。在肾上腺细胞研究中，输注雷尼替丁刺激基础醛固酮分泌，并抑制对血管紧张素II而非促肾上腺皮质激素（ACTH）的反应中醛固酮的释放。这些实验表明，雷尼替丁不太可能通过直接作用于垂体来改变垂体激素的分泌。然而，该药物可在体外影响醛固酮分泌，需要进一步的体内研究来阐明其意义。
